From: Robalini@aol.com
Subject: SNET: Littleton & Luvox
Date: 10 May 1999 01:05:27 -0400
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http://www.konformist.com/1999/colorado.htm
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Littleton & Drug Side Effects
Ian@Goddard.net
The Washington Post (4/29/99, A1) reports that columbine
gunman Eric Harris was on a prescription antidepressant,
a new drug called "Luvox." A net search finds that Luvox
"can activate mania in susceptible patients" (source:
http://www.begin.com/redoak/medications/luvox.html)
The manufacturers prescription insert says: "LUVOX Tablets
should be used cautiously in patients with a history of mania."
http://www.ocdresource.com/ocdresource.nsf/pages/Diagnosis+Luvox
Symptoms of "mania" include: "Provocative, intrusive, or aggressive
behavior" (see: http://mentalhelp.net/articles/grohol/bipolar.htm)
A National Institute of Mental Health webpage includes the following
mania symptoms (http://www.nimh.nih.gov/dart1/need2no/symptoms.htm):
Symptoms of Mania Include
* Inappropriate elation
* Inappropriate irritability
* Grandiose notions
* Disconnected and racing thoughts
* Markedly increased energy
* Poor judgment
* Inappropriate social behavior
All of which appear to be applicable to the actions and
grandiose ideas of Eric Harris, which included an plan
in which, after killing their fellow students, the two
would escape to an Island in Mexico and then return to
the US to crash a plane into New York City. Wow! Now
if that's not a "grandiose notion" pray tell what is?
It's important to note that The Washington Post article
says Eric Harris was the leader of the two dead gunmen.
So Dylan Klebold was following his friend who was on
a psychotropic drug that's known to activate mania,
which can manifest itself as aggressive behavior.
Dr. Ann Blake Tracy, author of "Prozac: Panacea or Pandora?,"
lists "aggressive or violent behavior" as a side effect of
antidepressants such as Luvox. Dr Tracy states that long-
term users of antidepressants can loose the distinction
between reality and dream. She says some patients enter
an "anesthetic sleep state" where they do things that
later they can't believe or recall they did (see:
http://www.geocities.com/HotSprings/3568).
Searching the MEDLINE database at the National Library
of Medicine website (http://igm.nlm.nih.gov) I found a
study by doctors from the Hadassah-Hebrew University
School of Medicine in Jerusalem, Israel that came
to this conclusion about Luvox, or fluvoxamine:
"Our case series suggests that fluvoxamine
may have the ability to induce or unmask manic
behavior in depressed patients. Clinicians are
alerted to monitor for this 'switching' effect..."
TITLE: Fluvoxamine-associated manic behavior:
a case series.
AUTHORS: Dorevitch A; Frankel Y; Bar-Halperin A;
Aronzon R; Zilberman L
SOURCE: Ann Pharmacother 1993 Dec;27(12):1455-7
CITATION IDS: PMID: 8305775 UI: 94138126
Some other studies I found @ http://igm.nlm.nih.gov :
TITLE: Mania and fluvoxamine.
AUTHORS: Burrai C, et al.
SOURCE: Am J Psychiatry. 1991 Sep;148(9):1263-4.
CIT. IDS: PMID: 1909099 UI: 91353783
TITLE: Fluvoxamine-associated mania/hypomania
in patients with obsessive-compulsive disorder.
AUTHORS: Jefferson JW, et al.
SOURCE: J Clin Psychopharmacol. 1991 Dec;11(6):391-2.
CIT. IDS: PMID: 1770160 UI: 92121482
There are a dozen or more studies on Prozac-induced
mania (http://igm.nlm.nih.gov). Both Prozac and Luvox
are selective serotonin reuptake inhibitors (SSRI).
It's only too clear that Eric Harris manifested the
known side effects of the drug and/or physiological
symptoms contraindicated for the drug, and thus he
should have (a) never been prescribed Luvox, or (b)
been taken off it; which is of course 100% apparent
only in hindsight. The Post didn't mention the drug's
side effects, only that the Marines rejected him since
he was on the drug (it may have hurt him in several ways).
------------------------------------------------------------
GODDARD'S JOURNAL: http://www.erols.com/igoddard/journal.htm
____________________________________________________________
Gunman on Luvox - Confirmed
From: Ian@Goddard.net
* LITTLETON GUNMAN TESTS POSITIVE FOR MANIA-INDUCING DRUG *
ABC's Colorado affiliate KCNC NEWS4 reports (5/4/99) [1]:
"[T]he coroner has released further toxicology
reports on Eric Harris, one of the two dead
suspects. Specialized testing shows levels of
Luvox in Harris' blood in a therapeutic range."
While doctors interviewed by The Washington Post [2] and
CNN [3] claim there's no link between Luvox and aggressive
behavior, the medical literature gives a different picture.
Luvox is the trade name for fluvoxamine, which research
shows can induce mania. A study found in the "American
Journal of Psychiatry" (9/91, page 1264) concludes:
"Our observations confirm the efficacy of
fluvoxamine [ Luvox ] in the treatment of
depression but suggest that this drug can
induce mania in some patients when it is
given at normal doses." [4]
One symptom of mania can be "aggressive behavior." [5]
Luvox is a selective serotonin reuptake inhibitor (SSRI).
About such drugs Dr. Jodi Worrel of the Western Missouri
Mental Health Center states: "Child and adolescent data
suggest worsening of aggression with SSRI treatment."[6]
Psychiatric-drug expert Dr. Peter Breggin states [7]:
"According to the manufacturer, Solvay, 4% of
children and youth taking Luvox developed mania
during short-term controlled clinical trials.
Mania is a psychosis which can produce bizarre,
grandiose, highly elaborated destructive plans..."
A study published in the "Journal of Clinical Psychiatry"
(July 1995, pages 288-96) states about another SSRI drug
similar to Luvox: "Fluoxetine-treated patients reported
an increased frequency of...anger or aggression." [8] A
study by researchers at the Hadassah-Hebrew University
School of Medicine in Jerusalem published in the "Annals
of Pharmacotherapy" concluded the following about Luvox:
"Our case series suggests that fluvoxamine
may have the ability to induce or unmask manic
behavior in depressed patients. Clinicians are
alerted to monitor for this 'switching' effect..."[9]
In the "American Journal of Psychiatry" 9-91 study,
patients suffering Luvox-induced mania were
not helped by the anti-mania drug lithium, indeed it seemed
to make them worse. Only when the use of Luvox stopped did
the patient's mania clear. Not only Luvox causes mania. In
a letter published in the "American Journal of Psychiatry"
(3/90, page 372), researcher Dr. Alan Lipschitz states:
"I would like to draw your attention to a
psychiatric aphorism that illuminates some
mood disorder mechanisms: Every antidepressant
that does not cure mania causes mania." [10]
So it seems mania is linked to many antidepressants.
Eric Harris, who was said to be the leader of the two
dead gunman, had been taking a mania-inducing drug and
displayed aggressive and unusual behavior indicative of
mania prior to his deadly shooting rampage at Columbine
High school, when, as tests prove, he was on that mania-
inducing drug, Luvox. (relevant http://drugawareness.org)
_________________________________________________________
[1] KCNC NEWS4: Columbine Shooting (5/4/99, 12:41 AM ET)
http://www.kcncnews4.com/prd1/now/now_template_utility.
call_proper_frameset?p_story=146544&p_who=kcnc&p_section=200
[2] The Washington Post: Shooter Used Often-Prescribed Drug:
http://search.washingtonpost.com/wp-srv/WPlate/1999-04/30/
016l-043099-idx.html
[3] CNN: Columbine shooter was prescribed anti-depressant:
http://cnn.com/HEALTH/9904/29/luvox.explainer/index.html
[4] American Journal of Psychiatry: Mania and Fluvoxamine.
C.Burrai, A.Bocchetta, M.Zompo, Sept.'91, (148)9, p.1263-4.
[5] Bipolar Disorder (Manic-Depression) Explained:
http://mentalhelp.net/articles/grohol/bipolar.htm
[6] The Psyche: Chronic Treatment of Aggressive Behavior.
By Jodi Worrel, Pharm.D., May 1998 Volume 3, Issue 5.
http://www.med.umkc.edu/thepsyche/pastissu/may98/index.html
[7] "Eric Harris was taking Luvox (a Prozac-like drug) at
the time of the Littleton murders." By Peter R. Breggin,
M.D., April 30, 1999: http://www.breggin.com/luvox.html
[8] Journal Of Clinical Psychiatry: Postmarketing surveillance
by patient self-monitoring: preliminary data for sertraline
versus fluoxetine. Fisher, Kent, Bryant, 7/95, 56(7):288-96.
[9] Annals Of Pharmacotherapy: Fluvoxamine-associated manic
behavior: a case series. A. Dorevitch, Y. Frankel, A. Bar-
Halperin, December 1993, Vol. 27 No. 12, pages 1455-7.
[10] American Journal of Psychiatry: Antidepressants and
mania. Alan Lipschitz, March 1990, Vol.147, No.3, p. 372.
Was the Littleton Shooting a Drug-Induced Mania?
http://www.erols.com/igoddard/littleton.htm
------------------------------------------------------------
GODDARD'S JOURNAL: http://www.erols.com/igoddard/journal.htm
____________________________________________________________
Gunman on Luvox - Confirmed
From: Ian@Goddard.net
The Nebraska Journal of Medicine reports
a case where a female patient with Obsessive
Compulsive Disorder became suicidal and was
hospitalized shortly after taking Luvox. Her
symptoms cleared after discontinuing Luvox
(accessed via: http://igm.nlm.nih.gov):
________________________________________________________
TITLE: Serotonin syndrome and fluvoxamine: a case study.
AUTHORS: Bastani JB; Troester MM; Bastani AJ
AUTHOR AFFILIATION: Dept. of Psychiatry, Bryan
Memorial Hospital, Lincoln, NE 68506, USA.
SOURCE: Nebr Med J 1996 Apr;81(4):107-9
CITATION IDS: PMID: 8628448 UI: 96212262
ABSTRACT:
OBJECTIVE: To report a serotonin syndrome reaction in a
patient taking fluvoxamine to replace an earlier SSRI
agent. CASE REPORT: A female patient with Obsessive
Compulsive Disorder on paroxetine after resurgence in her
obsessive ruminations was started on fluvoxamine 50 mg daily.
One week later she became suicidal and was hospitalized. The
fluvoxamine was increased to 50 mg morning and 100 mg bedtime
and the paroxetine was discontinued. Over the next few days
she began to have trouble with her concentration. A low grade
fever set in after she experienced auditory hallucinations.
Fluvoxamine was discontinued and she had an uneventful
recovery after twenty-four hours. ...[End Abstract Quote]
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